low iron levels and vitamins (cross posted)

Marjorie F.
on 5/14/12 11:12 pm - Coffeyville, KS
I also posted this on the Diet and Nutrition forum but thought I would get more views here:

I am 9 years post op from RNY and have been a very bad patient. I never got blood work done until recently and have been very inconsistant with taking vitamins. I am trying to get back on track WRT taking vitamins and getting my levels up. 

Since getting my labs done on April 5th I have started taking:

1 50,000iu Vitamin D/daily
3 doses Calcium Citrate plus D/daily  total 1890mg calcium 1500mg D
2 doses Prenatal multivitamin
1 B12 5,000mcg/daily sublingual
3 Perfect Iron (Carbonyl) 75mg/daily
1 Vitamin C 500mg/daily

My levels are as follows:
Hemoglobin 11.7 (normal)
hematocrit 37.1 (normal)
MCV 80.0 (low)
MCH 25.2 (low)
RBC Distribution Width 15.4% (high)
iron 18 (low)
tibc 495 (high)
sat tibc 4% (low)
Calcium 9.1 (normal)
vitamin D 11 (low)
PTH 78 (high) indicates Secondary HyperParaThyroidism
B12 182 (low)

My Dr. called and wants me to start taking rx iron ferrex 150mg (polysaccharide elemental iron) twice daily for 3 months. What level of iron would indicate getting iron infusions? Does the 150mg/twice daily sound like it will get my levels up? Am I taking enough B12 to get my level up? Am I taking enough vitamin C for the amount of iron I'm taking? Am I taking enough Calcium and Vitamin D? 

Any advice is appreciated.

Thanks,
Marjorie
 
JJ_
on 5/15/12 12:06 am
Hi Majorie,

My bariatric centre indicates that we should have 350 to 500 mcg/ day of B12.  However, if you are behind in your levels, you would definitely need to take more.

I supplement with Proferrin as it is a heme iron (non-constipating and you can take it along with vitamins or calcium, no need for Vitamin C.

Here is a post from a professional on the Ontario Board about iron:

I am a registered nurse, and work for the Province of Ontario's Blood Conservation Program.  I have spoken at a few Weight Loss Support Groups and welcome the opportunity to speak to any group that asks.  The following is excerpts from the word document that accompanies my presentation.

This information, is the basis of my current practice but in no way is it meant to supersede the advice of your physician and/or bariatric centre of excellence.  You are welcome to take from it what you need and or want. 

Anemia and the Surgical Bariatric Patient
By: Leona A. Dove RN, BScN

Anemia
is a prevalent diagnosis among the surgical weight loss community. The primary cause of this anemia is related to the absorption of components necessary to build healthy red blood cells.  Anemia is clinically defined as a HGB < 120 g/L in men and non-menstruating women and a HGB < 115 g/L in menstruating women. As a Blood Conservation Specialist, I tend to treat all patients whose HGB is < 120. Making allowances for the fact that women bleed once a month does not necessarily make that person feel any less symptomatic in terms of fatigue etc.

Hemoglobin (HGB)
is an iron derived blood protein that carries oxygen and nutrients to the tissue. It is what makes our red blood cells, and thus our blood red. Low hemoglobin means less than optimal oxygen and nutrients are getting to our tissues. Some of the symptoms of this lack of oxygen and nutrients getting to our tissues are directly related to the tissues not getting enough oxygen and nutrients (e.g. slow healing and infection at the site of surgery, moodiness because the brain is not getting enough oxygen etc). Other symptoms are related to our body’s reaction to not having enough oxygen and nutrients (e.g. Our respiratory rate increases to get more oxygen into our lungs, our heart beats faster to get more blood carrying less oxygen to our vital centres, our blood pressure drops to hold what blood we have in our vital core instead of sending it to our extremities etc).

As I mentioned HGB is an iron derived blood protein. There are three components necessary for the body to convert Iron to hemoglobin.

Iron-The building blocks of hemoglobin

Vitamin B12- The brick mason

Erythropoietin-The General Contractor

Anemia is a result of a lack of, or functional failure of, one of these three components. The type of anemia can be determined from a common blood test (a complete blood count) specifically two values of that count. Once the CBC is evaluated additional blood work may need to be ordered.  

Iron Deficient Anemia
Anemia related to low iron is the most commonly diagnosed anemia. If your body does not have enough iron to convert to hemoglobin, you will not have an adequate hemoglobin level. In the bariatric patient, the iron deficiency is often related to the decreased iron absorption surface. Eighty percent of the iron from our food is absorbed at the level of our stomach. Weight loss surgery significantly reduces the size of the stomach thus significantly reducing the absorption surface for iron as a result most Surgical Bariatric Patients need to increase the intake of iron rich foods and rely on iron supplements to ensure they have the “building blocks" necessary for HGB production.

Iron Rich Diet
It is nearly impossible to poison yourself eating foods naturally containing iron; as such this strategy is perhaps one of the easiest if not safest ways to increase the body’s iron reserve. There are two types of Iron we can get from our food:

Heme Iron: Found in animal protein sources, red meat, poultry (specifically the dark meat of the legs and thighs vs. the breast) and fish. Heme Iron is readily absorbed and used by the body, is not affected by what you eat and drink in conjunction with them and helps the body to absorb and use non-heme irons.

Non-Heme Iron: Found in plant protein sources, beans, lentils, whole grains, dried fruits, nuts, green leafy vegetables and some fruits. Non-Heme Iron is not as readily absorbed and used by the body and are affected by what you eat and drink with them. Heme Iron containing foods, and foods rich in Vitamin C (bell peppers, broccoli, strawberries, citrus fruit,
Cantaloupes) increase the absorption and use of non-heme iron. Foods containing Oxalates (coffee, tea, cola, and chocolate) and foods ri*****alcium (milk, cheese etc) block the absorption and use of    non-heme irons.

To Maximize The Absorption of Iron From your Food:

ü Remember iron is in colourful foods red meat, green leafy vegetables and the rich golden browns of whole wheat. If your food is grey because of age or over cooking what iron was in it is likely minimized.

ü Maximize the body’s absorption and use of Non-Heme Iron by consuming them with foods containing Heme Iron and/or foods rich in Vitamin C.

ü Avoid the consumption of oxalate and calcium containing foods for one hour before and after your Iron Rich Meal  

Iron Supplements
The arbitrary use of an iron supplement without the recommendation of a health care professional can be dangerous. Iron is a “fat stored" mineral, which can reach toxic levels, resulting in liver damage. If an iron supplement is recommended there is some valuable information you need to have.
There are two generations of iron supplements; the difference is related to where the iron is absorbed.

I.  Iron Salts (ferrous sulfate, ferrous Gluconate, ferrous Fumarate) are absorbed in the  stomach. They must be taken on an empty stomach (1 hour before a meal or 2 hours after a meal) to maximize its absorption. They cannot be taken with calcium containing medications or foods, aluminum salts based antacids (Maalox, gaviscon, Tums) or oxalate containing foods as these things block the absorption of the iron salt. The use of Vitamin C in conjunction with the Iron Salt will increase the absorption of the iron salt. Recent studies have also proven that the use of Proton Pump Inhibitors and H2 inhibitors (medications that reduce the acidity of the stomach “juices") inhibit the digestion and absorption of iron salts.
  

Things to know about Iron Salts

ü  Can cause black “tarry" or “sticky" constipated stools. Fastidious skin care is necessary after bowel movements to avoid painful skin irritation in this area.

ü Should not be taken with coffee, tea, milk, cola, or chocolate as these will block its absorption

ü Consider taking your iron salt supplement with a juice rich in Vitamin C to maximize its absorption. My personal favorite is a swallow of prune juice for two reasons: 

                                                        i.            Prune juice is a natural laxative                                                       ii.            Prune juice is rich in iron  

ü Can cause gastric irritation and GERD like symptoms, this can be minimized by remaining in an upright position for 30 minutes after taking the iron salt

ü  Antacids (Maalox, Gaviscon), or calcium supplements should not be taken within 30-60 minutes of the iron salt because its absorption will be blocked.

ü Absorption of Iron Salts is most effective when taken on an empty stomach (one hour before you eat or two hours after you eat). Personally and professionally I recommend two hours after you eat to decrease the gastric irritation and GERD like symptoms common to iron salts   

II.  
Non-Salt Iron Supplements

A. Proferrin is a bovine sourced HEME iron. It is absorbed in the small intestine

B. Polysaccharide Irons (FeraMAX, Triferritin) are manufactured irons also absorbed lower in the digestive tract. Severely Iron Deficient patients may be prescribed an intravenous form of polysaccharide iron, while beneficial in some cases this alternative will not be discussed today.
  Things to know about Heme and Polysaccharide Irons ü DO NOT need to be taken on an empty stomach

ü Are Not effected by the use of antacids, calcium supplements Proton Pump Inhibitors, or H2 Inhibitors

ü Are Not effected by Vitamin C consumption

ü DO NOT cause Gastric Irritation or GERD like symptoms

ü DO NOT usually cause black tarry, sticky or constipated stools.

The Great Supplemental Iron Debate

ü ODB most supplemental health plan will cover prescribed Iron Salts. 

Some supplemental health plans will cover Proferrin if bought with a prescription. 

Polysaccharide Iron Supplements are considered a dietary supplement (they have no DIN) and are not covered by either ODB or Supplemental health plan

ü Decreased absorption surfaces resultant from surgically decreasing the stomach size directly results in the decreased absorption of iron salts

ü Use of Proton Pump Inhibitors, and H2 inhibitors decrease the digestion and absorption of iron salts

ü Although exact location in the intestine where polysaccharide and heme irons are absorbed has not been mapped, it is believed that polysaccharide irons are absorbed still lower than Heme irons and as such are the supplement of choice for Duodenal Switch patients

ü Heme irons are derived from animal sources vegetarians, and certain religious groups may object to using such derivatives

ü Physicians and dieticians are more familiar, and thus more comfortable with the use of Iron Salts as opposed to Heme and Polysaccharide Irons   

B12 Deficient Anemias

As mentioned earlier B12 is the brick mason of HGB production. B12 stimulates the conversion of Iron into Hemoglobin. Without sufficient B12 adequate Iron reserves cannot be converted into oxygen and nutrients carrying Hemoglobin. The absorption of B12 requires Intrinsic Factor which is secreted by the stomach. The area where Intrinsic Factor is excreted is severely reduced and/or completely lost during the surgical reduction of the stomach. Without sufficient Intrinsic Factor, B12 from food or oral supplements cannot be absorbed. It is recommended that Surgical Bariatric Patients take a sublingual (under the tongue) B12 supplement or regular B12 injections.  

Erythropoietin and Anemias

Erythropoietin
is a hormone manufactured and excreted by the kidneys; it is the substance that triggers the bone marrow to use hemoglobin to produce Red Blood Cells. It is very possible to have adequate stores of Iron and B12 and still be anemic related to an insufficiency of erythropoietin. This malady is common in patients with impaired kidney function. The reason why I mention it however is that it is possible to use synthetic erythropoietin (Eprex) in conjunction with oral and sometimes intravenous iron supplements to rapidly boost the hemoglobin of patients with severe iron deficient anemias.  

Conclusion

Anemia is a broad spectrum diagnosis, individually honed through the assessment of the patient and their lab work. Just as every patient is unique so is the treatment of their anemia. I urge you all to advocate for yourself, be health care consumers, educate yourselves and in turn educate the health care professional that is caring for you.    
 
goddessgrrl
on 5/15/12 6:06 am - VA
JJ, thank you so much for all this vital information. I read every word (& understood almost every word lol)! I'm going to save this. I almost tripped I ran so fast to get my B12 & vitamins in after I read this!

View more of my photos at ObesityHelp.com

 

     

JJ_
on 5/15/12 6:50 am
LOL, I know I made sure I have been getting my vitamins in too :)  I have saved the above information on my computer so I can access it anytime.  Keep healthy :)

Judy
H.A.L.A B.
on 5/15/12 8:56 am

Things to know about Heme and Polysaccharide Irons ü DO NOT need to be taken on an empty stomach

ü Are Not effected by the use of antacids, calcium supplements Proton Pump Inhibitors, or H2 Inhibitors


There are studies that indicate that heme iron absorbtion can be affected by calcium. Please check that.
i.e.


http://www.ajcn.org/content/68/1/3.full.pdf

Most dietary factors influencing iron absorption probably exert their action within the gastrointestinal lumen by making iron more or less bioavailable for absorption. The effect of calcium, however, is different. The reported inhibition of iron absorption by calcium is the same for nonheme and heme iron (2, 11). Because heme and nonheme iron are absorbed by different receptors on the mucosal surface, inhibition by calcium must be located within the mucosal cell at some transfer step common to the 2 kinds of iron. This difference between calcium and other factors influencing iron absorption would by itself not cause methodologic problems (...)

Hala. RNY 5/14/2008; Happy At Goal =HAG

"I can eat or do anything I want to - as long as I am willing to deal with the consequences"

"Failure is not falling down, It is not getting up once you fell... So pick yourself up, dust yourself off, and start all over again...."

poet_kelly
on 5/15/12 12:18 am - OH
What was your ferritin level?  Usually people do infusions when that gets very low, like under 10.  But that is something to discuss with your doctor.

Yes, you're taking enough B12 to get your level up but it will take a little while.  You need your B12 to be above 550, preferrable around 1000.  Right now, it's so low you may end up with permanent nerve damage in your hands and feet.

Yes, you're taking enough C for the iron - you need 200 mg C for every 30 mg iron.

You are taking enough calcium and D now.  You need to get your D level up to at least 80.

The reason your PTH is probably so high is because you have not been getting enough calcium.  What happens is, your parathyroid gland makes extra parathyroid hormone, which sucks calcium out of your bones to keep the calcium level in your blood normal.  That's because if it gets too low, your heart can't beat properly.

So you should get a bone density scan and see what your bones look like.

View more of my photos at ObesityHelp.com          Kelly

Please note: I AM NOT A DOCTOR.  If you want medical advice, talk to your doctor.  Whatever I post, there is probably some surgeon or other health care provider somewhere that disagrees with me.  If you want to know what your surgeon thinks, then ask him or her.    Check out my blog.

 

lanagirl
on 5/15/12 3:05 am
Kelly, in the post above the lady breaks down the different kinds of iron but I don't see carbonyl iron listed. Do you know which catagory it falls under?
     
          
poet_kelly
on 5/15/12 3:24 am - OH
I believe it is non-heme iron and it is all elemental iron, no iron salts.

View more of my photos at ObesityHelp.com          Kelly

Please note: I AM NOT A DOCTOR.  If you want medical advice, talk to your doctor.  Whatever I post, there is probably some surgeon or other health care provider somewhere that disagrees with me.  If you want to know what your surgeon thinks, then ask him or her.    Check out my blog.

 

Dragonryder2
on 5/15/12 12:27 am - NM
Hello Marjorie;

I'm really glad you are getting back on track.  You could have ended up very sick.

I just started Proferrin for the very reason that JJ stated.  It is heme iron and for my body seems to be absorbed better and I don't have to worry so much about when I take it.  I got it from VitaLady.com and it was $53 for 90.  A little expensive, but after you get your level up I think you would drop back to one a week.

I am also changing my d-3 to the 50,000 IU dry tablet.  I have been taking LOTS of the oil based Vit D and I can't get my levels up and someone suggested trying the other type so I am.

How about your Folate.  I didn't see that listed and Potassium, also.  Lots of important things to check when you are like we are.  It takes at least 2x the RDA of all Vits and Minerals for us because we don't absorb them like normal folks.

Good luck and keep us posted on how you are doing.
H.A.L.A B.
on 5/15/12 8:57 am
Things to know about Heme and Polysaccharide Irons ü DO NOT need to be taken on an empty stomach

ü Are Not effected by the use of antacids, calcium supplements Proton Pump Inhibitors, or H2 Inhibitors


There are studies that indicate that heme iron absorbtion can be affected by calcium. Please check that.
i.e.


http://www.ajcn.org/content/68/1/3.full.pdf

Most dietary factors influencing iron absorption probably exert their action within the gastrointestinal lumen by making iron more or less bioavailable for absorption. The effect of calcium, however, is different. The reported inhibition of iron absorption by calcium is the same for nonheme and heme iron (2, 11). Because heme and nonheme iron are absorbed by different receptors on the mucosal surface, inhibition by calcium must be located within the mucosal cell at some transfer step common to the 2 kinds of iron. This difference between calcium and other factors influencing iron absorption would by itself not cause methodologic problems (...)

Hala. RNY 5/14/2008; Happy At Goal =HAG

"I can eat or do anything I want to - as long as I am willing to deal with the consequences"

"Failure is not falling down, It is not getting up once you fell... So pick yourself up, dust yourself off, and start all over again...."

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